{"product_id":"dsip-nasal-spray","title":"DSIP Nasal Spray","description":"\u003cp\u003e\u003cstrong\u003eDSIP — The Sleep Peptide\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStudied for delta-wave sleep activity\u003c\/li\u003e\n\u003cli\u003eNonapeptide that crosses the blood–brain barrier\u003c\/li\u003e\n\u003cli\u003eAlso investigated in stress and analgesia research\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003eDSIP nasal spray, prepared as a metered intranasal solution for laboratory research. Available in 5mg.\u003c\/p\u003e\n\u003cp\u003eEach unit is reconstituted and filled individually at the point of order — we never hold pre-reconstituted stock on a shelf. Made-to-order items are dispatched within 48 hours.\u003c\/p\u003e\n\n\u003ch2\u003eKey Specifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eProduct format:\u003c\/strong\u003e Metered nasal spray, made to order\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvailable sizes:\u003c\/strong\u003e 5mg\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource compound:\u003c\/strong\u003e DSIP — \u003ca href=\"\/products\/dsip\"\u003ealso available as a lyophilised powder vial\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) — linear nonapeptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e Verified by HPLC on every batch — the measured figure for your lot is published on its certificate of analysis\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePreparation:\u003c\/strong\u003e Reconstituted and filled to order, never pre-mixed\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Refrigerate on arrival; keep away from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDispatch:\u003c\/strong\u003e Within 48 hours (made to order)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIntended use:\u003c\/strong\u003e Laboratory research use only\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eWhy the intranasal format\u003c\/h2\u003e\n\u003cp\u003eDSIP is a small, unmodified nonapeptide with free amino and carboxyl termini, which makes it a poor candidate for oral delivery — peptides of this class are rapidly degraded by gastrointestinal proteases and first-pass metabolism before reaching circulation. Intranasal delivery avoids that route entirely, and offers direct nose-to-brain transport along the olfactory and trigeminal nerve pathways, which partially bypasses the blood-brain barrier.\u003c\/p\u003e\n\u003cp\u003eIn DSIP's case that rationale is worth stating precisely: the peptide is reported to cross the blood-brain barrier, and the published human studies on it used intravenous infusion rather than the intranasal route. Intranasal preparation is used in research settings for the practical reasons above, not because the original clinical literature was built on it.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Focus\u003c\/h2\u003e\n\u003cp\u003eDSIP was isolated in 1977 from the cerebral venous blood of rabbits undergoing induced slow-wave sleep, and takes its name from the delta-wave EEG activity observed in those experiments. Early human work examined its influence on disturbed sleep, with published studies reporting shorter sleep onset latency and improved sleep efficiency.\u003c\/p\u003e\n\u003cp\u003eResearch interest has since extended beyond sleep, into stress-axis and corticotropin regulation, thermoregulation, analgesia, opioid withdrawal models and antioxidant activity — which is why the literature often describes DSIP as multifunctional rather than sleep-specific.\u003c\/p\u003e\n\u003cp\u003eIt is worth being clear about the state of the evidence: despite the name, DSIP's status as an endogenous sleep factor remains unresolved. No corresponding gene, precursor protein or receptor has been identified, and findings across studies have been inconsistent — a 2006 review in the \u003cem\u003eJournal of Neurochemistry\u003c\/em\u003e characterised it as a still-unresolved riddle. DSIP remains an active subject of laboratory investigation rather than a settled one.\u003c\/p\u003e\n\n\u003ch2\u003eTesting \u0026amp; Certificates of Analysis\u003c\/h2\u003e\n\u003cp\u003eSprays are prepared from the same independently tested material as our powder vials — HPLC purity and mass-spectrometry identity, certified per batch and published on our \u003ca href=\"\/pages\/lab-results\"\u003elab results page\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eReturns\u003c\/h2\u003e\n\u003cp\u003eMade-to-order items are prepared individually for you and are exempt from the 14-day cancellation right under the Consumer Contracts Regulations 2013. They cannot be returned or refunded unless faulty, damaged or not as described. See our \u003ca href=\"\/policies\/refund-policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eFor laboratory research use only.\u003c\/strong\u003e All products sold by PepSource are strictly for laboratory research purposes and are not intended for human or veterinary consumption. No dosing, administration or physiological guidance is provided.\u003c\/p\u003e","brand":"PEP SOURCE","offers":[{"title":"5mg","offer_id":53882811023688,"sku":null,"price":23.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0974\/5593\/1720\/files\/dsip-nasal-spray-5mg-pepsource.png?v=1787354797","url":"https:\/\/pepsource.co.uk\/products\/dsip-nasal-spray","provider":"PepSource","version":"1.0","type":"link"}