KPV

KPV — The Anti-Inflammatory Tripeptide

• C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH)
• Studied in intestinal and skin inflammation models
• Small enough to be carried by the PepT1 peptide transporter

Overview

KPV is a tripeptide with the sequence Lys-Pro-Val, corresponding to residues 11–13 at the C-terminus of α-MSH. It was identified as the fragment that carries much of the parent hormone's anti-inflammatory activity in laboratory models, without the melanotropic (pigmentation) activity associated with the full-length peptide. It is supplied as a lyophilised powder in a sealed vial for laboratory and in-vitro research.

PepSource supplies KPV in 10mg vials. Every batch is independently third-party tested for HPLC purity and mass-spectrometry identity, and the certificate of analysis for the batch you receive is published on our lab results page.

Key Specifications

• Product format: Lyophilised powder, sealed vial
• Available sizes: 10mg vial
• Sequence: Lys-Pro-Val (KPV) — linear tripeptide
• Molecular formula: C₁₆H₃₀N₄O₄ — molecular weight approximately 342.4 Da
• CAS number: 67727-97-3
• Purity: Verified by HPLC on every batch — the measured figure for your lot is published on its certificate of analysis
• Storage: Store sealed vials cool, dry and away from light; freeze for long-term storage
• Reconstitution: Bacteriostatic water — see our reconstitution guide
• Intended use: Laboratory research use only

Research Focus

Most published work on KPV concerns inflammation. In cell and animal studies it has been reported to reduce NF-κB activation and the release of pro-inflammatory cytokines, and it has been investigated in rodent models of colitis, where its uptake by the intestinal peptide transporter PepT1 made it a subject of interest for gut-targeted delivery research, including nanoparticle formulations.

KPV has also been examined in skin and wound models, and it is one of the components of the KLOW research blend alongside BPC-157, GHK-Cu and TB-500.

The evidence base is almost entirely preclinical. KPV is not an approved medicine, and findings from cell and animal models should not be read as evidence of any effect in people.

Testing & Certificates of Analysis

Each batch is tested by an independent analytical laboratory for HPLC purity and mass-spectrometry identity before release. Certificates are published per batch and searchable by lot code on our lab results page — you can verify the exact vial you were sent.

For laboratory research use only. All products sold by PepSource are strictly for laboratory research purposes and are not intended for human or veterinary consumption. No dosing, administration or physiological guidance is provided.