DSIP

DSIP — The Sleep Peptide

• Studied for delta-wave sleep activity
• Nonapeptide that crosses the blood–brain barrier
• Also investigated in stress and analgesia research

Overview

DSIP (delta sleep-inducing peptide) is a nonapeptide first isolated in 1977 from the cerebral venous blood of rabbits undergoing induced slow-wave sleep. It carries the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and is supplied as a lyophilised powder in a sealed vial for laboratory and in-vitro research.

PepSource supplies DSIP in 5mg vials. Every batch is independently third-party tested for HPLC purity and mass-spectrometry identity, and the certificate of analysis for the batch you receive is published on our lab results page.

Key Specifications

• Product format: Lyophilised powder, sealed vial
• Available sizes: 5mg vial
• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) — linear nonapeptide, no disulfide bonds
• Molecular formula: C₃₅H₄₈N₁₀O₁₅ — molecular weight approximately 848.8 Da
• CAS number: 62568-57-4
• Purity: Verified by HPLC on every batch — the measured figure for your lot is published on its certificate of analysis
• Storage: Store sealed vials cool, dry and away from light; freeze for long-term storage
• Reconstitution: Bacteriostatic water — see our reconstitution guide
• Intended use: Laboratory research use only

Research Focus

DSIP takes its name from the delta-wave EEG activity observed after infusion in the original rabbit experiments. Early human work examined its influence on disturbed sleep, with published studies reporting shorter sleep onset latency and improved sleep efficiency, including effects measured on the following night rather than only immediately after administration.

Research interest has since extended well beyond sleep. Published work has examined DSIP in relation to stress-axis and corticotropin regulation, thermoregulation, analgesia, opioid withdrawal models and antioxidant activity — which is why the literature often describes it as multifunctional rather than sleep-specific.

It is worth being clear about the state of the evidence: despite the name, DSIP's status as an endogenous sleep factor remains unresolved. No corresponding gene, precursor protein or receptor has been identified, and findings across studies have been inconsistent — a 2006 review in the Journal of Neurochemistry characterised it as a still-unresolved riddle. DSIP remains an active subject of laboratory investigation rather than a settled one.

Testing & Certificates of Analysis

Each batch is tested by an independent analytical laboratory for HPLC purity and mass-spectrometry identity before release. Certificates are published per batch and searchable by lot code on our lab results page — you can verify the exact vial you were sent.

For laboratory research use only. All products sold by PepSource are strictly for laboratory research purposes and are not intended for human or veterinary consumption. No dosing, administration or physiological guidance is provided.