DSIP Pen Refill

DSIP — The Sleep Peptide

• Studied for delta-wave sleep activity
• Nonapeptide that crosses the blood–brain barrier
• Also investigated in stress and analgesia research

Overview

DSIP pen refill cartridge, supplied ready to insert into a peptide pen. Available in 5mg.

Each cartridge is reconstituted and filled individually at the point of order — we never hold pre-reconstituted stock on a shelf. Made-to-order items are dispatched within 48 hours.

Key Specifications

• Product format: Pre-filled pen cartridge, made to order
• Available sizes: 5mg
• Source compound: DSIP — also available as a lyophilised powder vial
• Also available as: DSIP nasal spray
• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) — linear nonapeptide
• Purity: Verified by HPLC on every batch — the measured figure for your lot is published on its certificate of analysis
• Preparation: Reconstituted and filled to order, never pre-mixed
• Storage: Refrigerate on arrival; keep away from light
• Dispatch: Within 48 hours (made to order)
• Intended use: Laboratory research use only

Research Focus

DSIP was isolated in 1977 from the cerebral venous blood of rabbits undergoing induced slow-wave sleep, and takes its name from the delta-wave EEG activity observed in those experiments. Early human work examined its influence on disturbed sleep, with published studies reporting shorter sleep onset latency and improved sleep efficiency.

Research interest has since extended beyond sleep, into stress-axis and corticotropin regulation, thermoregulation, analgesia, opioid withdrawal models and antioxidant activity — which is why the literature often describes DSIP as multifunctional rather than sleep-specific.

It is worth being clear about the state of the evidence: despite the name, DSIP's status as an endogenous sleep factor remains unresolved. No corresponding gene, precursor protein or receptor has been identified, and findings across studies have been inconsistent — a 2006 review in the Journal of Neurochemistry characterised it as a still-unresolved riddle. DSIP remains an active subject of laboratory investigation rather than a settled one.

Testing & Certificates of Analysis

Cartridges are filled from the same independently tested material as our powder vials — HPLC purity and mass-spectrometry identity, certified per batch and published on our lab results page.

Returns

Made-to-order items are prepared individually for you and are exempt from the 14-day cancellation right under the Consumer Contracts Regulations 2013. They cannot be returned or refunded unless faulty, damaged or not as described. See our refund policy.

For laboratory research use only. All products sold by PepSource are strictly for laboratory research purposes and are not intended for human or veterinary consumption. No dosing, administration or physiological guidance is provided.